Small ball continued with the Chargers' Cameron Dicker kicking a 32-yard field goal for a 5-3 Chargers lead with 7:32 left in the first half.
The Chargers pushed that lead to 12-3 with 12 seconds left in the half on Justin Herbert's 15-yard touchdown pass to Ladd McConkey. The drive was set up by RJ Mickens' interception on a Rodgers overthrow of DK Metcalf. It gave the Chargers the ball at the Pittsburgh 38 with 2:28 left in the half.
The Steelers went into the halftime locker room with only 3 first downs, 0-for-6 on third downs, and 85 yards of total offense. Rodgers was 7-for-14 for 64 yards and an interception in the first half.
The Chargers added to their lead midway through the third quarter when Dicker booted a career-long 59-yard field goal. The kick, with 6:07 to play in the third quarter, gave the Chargers a 15-3 lead.
The Steelers made their initial foray into the red zone early in the fourth quarter. Warren took a screen pass 18 yards to the LA 14, but the drive stalled at the 10, from where Rodgers threw incomplete on second, third, and fourth downs.
The Chargers responded with a touchdown six plays later to put the game away. A 58-yard catch-and-run by McConkey put the ball at the Pittsburgh 13, and two plays later Kimani Vidal ran for a 2-yard touchdown to boost the Chargers' lead to 22-3 with 9:26 remaining.
Dicker's 42-yard field goal for the Chargers with 4:54 left pushed the lead to 25-3.
A Rodgers 27-yard pass over the middle to Roman Wilson gave the Steelers their only touchdown and set the final score at 25-10.
Thanks to the final drive, the Steelers finished with 221 yards of total offense. Rodgers completed 16 of 31 passes for 161 yards and a passer rating of 50.6, his lowest of the season.
Warren was the Steelers' rushing leader with 70 yards on 14 carries.
Defensively, Patrick Queen's 12 tackles led the Steelers. Alex Highsmith had 2 of the Steelers' 5 sacks.