Arizona Cardinals receiver Marvin Harrison Jr. underwent surgery for appendicitis and will miss Sunday’s game against the visiting San Francisco 49ers, coach Jonathan Gannon said Wednesday.
Harrison, 23, has 34 catches for 525 yards and four touchdowns in nine starts this season for the Cardinals (3-6). Those numbers are all second on the team behind star tight end Trey McBride.
Breaking: Cardinals WR Marvin Harrison Jr. underwent surgery for appendicitis and is out for at least this week and possibly longer, head coach Jonathan Gannon announced. pic.twitter.com/AIOgqRHOuL
— ESPN (@espn) November 12, 2025
More on Marvin Harrison Jr.
Marvin Harrison Jr. had just three catches for 44 yards in Arizona’s 16-15 setback to San Francisco in Week 3.
He has totaled 96 receptions for 1,410 yards and 12 touchdowns in 26 career games since the Cardinals selected him with the fourth overall pick of the 2024 NFL Draft out of Ohio State.
–Field Level Media
More on the San Francisco 49ers vs. Arizona Cardinals matchup
The San Francisco 49ers will look to bounce back from a tough loss against the Los Angeles Rams when they take the field this weekend, but will Brock Purdy or Mac Jones be under center?
49ers head coach Kyle Shanahan met with the media on Tuesday to share an update on Purdy, who is ramping up aggressiveness in practice as he eyes a return on Sunday in his home state of Arizona to face the Cardinals.
Will Shanahan weigh the play of Jones, who has looked strong while filling in for Purdy? Will WR Ricky Pearsall be in the mix to return as well?
Here are Shanahan’s full comments on Brock Purdy, Ricky Pearsall, and more as the 49ers prepare the face the Cardinals.
Shanahan: Brock Purdy (toe) ramping up, getting closer to return
Upcoming San Francisco 49ers Schedule
Sunday, November 16th – @ Arizona Cardinals – 1:05 PM PT
Monday, November 24th – vs. Carolina Panthers – 5:15 PM PT
Sunday, November 30th – @ Cleveland Browns – 10:00 AM PT
Sunday, December 7th – BYE WEEK
Sunday, December 14th – vs. Tennessee Titans – 1:25 PM PT
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