2. Red-zone defense
When two good teams like Philadelphia and Detroit match up, the difference between winning and losing usually comes down to turnovers, third-down efficiency and who takes better advantage of their red-zone opportunities. The latter will be particularly key for Detroit's defense as Philadelphia comes into Sunday's contest with the No. 1 red-zone scoring offense in the NFL at 81.0 percent.
Detroit's defense hasn't been particularly good keeping opponents out of the end zone when they reach the red zone this season, ranking 25th by allowing a touchdown 66.7 percent of the time.
3. St. Brown vs. DeJean
Amon-Ra St. Brown is currently fourth among all NFL receivers in receptions (64), fifth in receiving yards (693) and second in touchdown receptions (8). He's Detroit's top weapon in the passing game and quarterback Jared Goff’s go-to target in the red zone and on third down. St. Brown has at least five receptions in eight consecutive games and 57 career games since entering the NFL in 2021.
Eagles versatile defensive back Cooper DeJean plays both in the slot and out wide, but two thirds of his snaps have come from the slot where teams are completing 61.4 percent of their passes (27-for-44) with an 86.4 rating and just one touchdown this season when throwing at DeJean.