Manchester United will next face Everton at Old Trafford in the Premier League on November 24.
The Red Devils are unbeaten in the last five games but will look to return to winning ways after two consecutive draws.
United head coach Ruben Amorim will have a big decision to make with Benjamin Sesko expected to be sidelined for the clash.
The 22-year-old suffered a knee injury against Tottenham Hotspur and had to be taken off despite coming on in the second half.
Sesko also had to withdraw from the November international fixtures, though United have yet to confirm the severity of his injury.
A recent report from Sky Sports revealed that the striker will miss at most a month of football.
Kobbie Mainoo has waited long enough for a start
We believe Amorim must use this opportunity to give Kobbie Mainoo his first start of the 2025-26 Premier League season.
Matheus Cunha is expected to start as a centre-forward in the absence of the Slovenia international.
The manager should allow Bruno Fernandes to roam from his favoured left-sided number 10 role, creating a perfect midfield opening for Mainoo.
Fernandes put in a world-class display in Portugal’s 9-1 win over Armenia on Saturday.
He netted a hat-trick and orchestrated multiple goals, showcasing his unrivalled creativity and finishing ability.
The 31-year-old showed why he is one of the best attacking midfielders in Europe and how lethal he can be when given the freedom to venture forward.
Amorim is hell-bent on using Fernandes in a deeper role but has shown a willingness to adapt based on the opposition.
Mainoo has played for only 138 minutes in the league this season, far less than what he truly deserves.
If opportunities remain scarce, he may push for a temporary move in January to gain regular playing time.
The United academy graduate must be given a chance in the number eight position with Casemiro partnering him in the midfield.
Mainoo possesses the attacking flair and ability to win duels.
He could prove to be useful against the Toffees, and the maiden start of this campaign could also boost his confidence.
United face a hectic schedule in December and January, with the festive fixtures and the FA Cup creating a testing run.
Amorim must ensure fringe players like Mainoo are match-ready and sharp, capable of stepping in and delivering when the club needs them most.
Stats from Fotmob.com