Manchester United manager Ruben Amorim could hand three players their first Premier League start of the season against Everton.
The Toffees are set to travel to Manchester to face the Red Devils on November 24.
Benjamin Sesko is expected to be sidelined for a month after sustaining a knee injury against Tottenham Hotspur.
Joshua Zirkzee could make his maiden start of the 2025-26 campaign.
He has played only 82 minutes in the English top flight this campaign, with Amorim trusting Sesko or Matheus Cunha to lead the line.
The Dutch international arrived at Old Trafford from Bologna last summer but scored only three league goals.
United have recently adopted the approach of playing more direct football rather than building up play from deep.
Zirkzee could serve as a decent target man and would allow Bryan Mbeumo to make runs beyond him.
This could also be his final opportunity to save his United career, considering how ruthless INEOS were with Rasmus Hojlund after one poor season.
Kobbie Mainoo could also be named in the starting XI if Amorim allows Bruno Fernandes to play in an advanced role.
Fernandes showed a world-class attacking display, netting a hat-trick in Portugal’s 9-1 win over Armenia over the weekend.
Mainoo’s only start of this campaign came in the defeat to Grimsby Town in the Carabao Cup.
The 20-year-old is a generational talent and deserves far more game time than he is getting at Old Trafford this season.
The third name on our list is Lisandro Martinez.
The 27-year-old is expected to be fully fit for the Everton clash after returning to team training in recent weeks.
He last featured in February against Crystal Palace when he suffered an anterior cruciate ligament injury.
There is no doubt that Martinez is one of the best ball-playing centre-backs in the league and his inclusion will elevate United’s ability to dominate possession.
Stats from Fotmob.com