Bleacher Report
Gagnon: Texans ( 5.5)
Houston's defense has been killing it, and the Texans really need this. They're at home, and the Bills are traveling while banged-up on short rest. Buffalo's shoddy run defense should allow the Texans to control the pace to an extent as they keep this one close.
Hanford: Bills (-5.5)
There are more reasons to pick Houston to cover here than there are to back Buffalo, but I'm choosing to ride with Josh Allen. The Texans' defense has been dominant all season, but the Bills quarterback will be its toughest task yet.
The Bills haven't been able to stop anyone defensively, especially on the ground, but I'm not sure I see Woody Marks and the Texans' ground attack exploiting that consistently.
Davis Mills will be under center again on a short week for the injured C.J. Stroud, and I like Buffalo's pass defense to make enough plays to give its team a seven-point win as Allen stays undefeated for his career on Thursday Night Football.
Predictions
Bills: Davenport, Hanford, Knox, O'Donnell, Sobleski
Texans: Gagnon, Moton