Now languishing in the bottom half of the table, Slot's dreams of defending his title are in ruins, and the Dutchman is under intense scrutiny to turn things around or face the previously unthinkable prospect of being sacked.
However, former manager Klopp had urged patience at the start of the season when Liverpool were beginning to show signs of struggle under Slot, although not to the extent they are now.
The German called for fans to give his successor time, as the team was undergoing a transition period, something that is clearly evident now as Slot grapples with integrating £450million worth of summer signings effectively.
Looking back on last year's managerial handover, Klopp said on The Diary of a CEO podcast: "We had a lot of contact after that. He's a super good guy. He got the best out of this team, and they became champions in an incredible manner.
"It's not about Arne showing the world what he can do - it's about getting the best out of the team. That's exactly what he did.
"Change always has an impact. And change always needs time.
"If he keeps the exact same team as last season - Darwin Nunez still there, Luis Diaz still there, for example - they start playing and have problems, [people say] 'We need change.'"
"Now the new guys are there, and they are really good players. It's just not working out at the minute."
Summarising his view in three words, Klopp concluded: "Development needs time," before adding: "Nobody can change that. People need time to adapt. It's all good."
Yet despite that view, there are issues Slot must tackle straight away. Particular choices, such as continuing with record acquisition, Alexander Isak leading the attack instead of Hugo Ekitike, and the absence of midfield equilibrium in the squad, have frustrated fans.
Liverpool's defensive woes have been a recurring theme since the start of the season, with Ibrahima Konate and Virgil van Dijk both noticeably struggling with form.
Injuries to Conor Bradley and Jeremie Frimpong have forced Dominik Szoboszlai into an unfamiliar right-back role, leaving many baffled as to why the Dutch manager didn't opt to play Joe Gomez in that position.