Tonight, the Carolina Panthers are +7.5 underdogs as they head to San Francisco to face the 49ers. Here are the top DFS picks and prop bets for the game:
Captain: Christian McCaffrey, RB, San Francisco ($18,600)
McCaffrey has been an elite fantasy asset for years, and this year has been no different for the injury-riddled 49ers. Not many non-quarterbacks are going to give you this type of floor/ceiling combination. The Panthers are giving up over 4.5 yards per carry, and McCaffrey is near even money to score tonight. Lock him in and get different elsewhere.
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Contrarian Captain Consideration: Bryce Young, QB, Carolina ($13,800)
Flex: Tetarioa McMillan, WR, Carolina ($9,400)
Nov 16, 2025; Atlanta, Georgia, USA; Carolina Panthers wide receiver Tetairoa McMillan (4) runs with the ball in the second half against the Atlanta Falcons at Mercedes-Benz Stadium. Mandatory Credit: Dale Zanine-Imagn Images
McMillan should be plenty busy with Carolina projected to be playing from behind all game. The rookie has been pretty consistent and received 8+ targets in 8 of the 11 games this year. This 49ers secondary has given up the 4th most fantasy points per game to wide receivers.
Flex: George Kittle, TE, San Francisco ($8,600)
Kittle is coming off back-to-back 20+ fantasy point performances and looks dominant after an injury cost him a month of action. He has a great rapport with Brock Purdy, and I expect things to keep rolling. While the Panthers have been solid on the whole against the position, some of the better tight ends in the league like McBride (6/78) and Johnson (4/92/1) have had nice games against them.
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Flex Considerations: Rico Dowdle, RB, Carolina ($10,400)Brock Purdy, QB, San Francisco ($10,000)Bryce Young, QB, Carolina ($9,200)Ricky Pearsall, WR, San Francisco ($7,600)Xavier Legette, WR, Carolina ($6,400)
Bargain Bin Flex: Kyle Juszczyk, RB, San Francisco ($1,400)
The kickers are certainly in play tonight, as well as the Carolina tight ends (Sanders/Tremble), but most of the volume for these teams is concentrated above the $5,000 threshold. I don’t mind a complete dumpster dive with Juszczyk as he’s 2x the value of his price tag in 6 games this year. His second touchdown could win it all for you in a large field if you are willing to gamble.
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Bargain Bin Flex Considerations
Sep 21, 2025; Charlotte, North Carolina, USA; Carolina Panthers running back Chuba Hubbard (30) carries the ball during the second half against the Atlanta Falcons at Bank of America Stadium. Mandatory Credit: Cory Knowlton-Imagn Images
Chuba Hubbard, RB, Carolina ($4,400)Jalen Coker, WR, Carolina ($4,000)Kendrick Bourne, WR, San Francisco ($3,800)Brian Robinson Jr, RB, San Francisco ($3,400)Demarcus Robinson, WR, San Francisco ($3,000)Ja’Tavion Sanders, TE, Carolina ($2,800)Tommy Tremble, TE, Carolina ($2,400), Matt Gay, K, San Francisco ($5,000) Ryan Fitzgerald, K, Carolina ($4,800)49ers DST ($4,600)
Best Bets for MNF Week 12
Final Score: Carolina 21, San Francisco 35
49ers come out and handle business in the healthiest spot they’ve been in pretty much all year. San Francisco covers with Carolina scoring late to secure the over.
PrizePicks (Week 11: 2-2, Overall: 17-26-1)
NFL: Updated list of teams with the most passing yards after Week 10
San Francisco 49ers tight end George Kittle (85) celebrates after getting a first down during the second quarter against the Los Angeles Rams at Levi’s Stadium. Credit: Kyle Terada-Imagn Images
George Kittle OVER 57.5 Receiving Yards
Christian McCaffery OVER 45.5 Receiving Yards
Bryce Young OVER 204.5 Passing Yards
Ja’Tavion Sanders OVER 17.5 Receiving Yards
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