Believe it or not, the winner of tonight’s Monday Night Football game will be sitting in playoff position. That’s a surprising situation for one of these teams in particular, as the Carolina Panthers have found some winning ways and are 6-2 over their last eight games.
The Panthers are in a tie with the Tampa Bay Buccaneers for the NFC South division lead as Carolina heads into Monday night’s matchup with the San Francisco 49ers. A win for Carolina would put them a half-game up on Tampa Bay, who lost big to the Rams on Sunday night, and would place them in the 4th seed in the NFC playoff picture.
The 49ers, meanwhile, are 7-4 and tied with the Detroit Lions for the final Wild Card spot heading into tonight. If they win this game, they would hold on to that slot while keeping Carolina out of the lead in their division for the time being.
Still, San Francisco comes in as big favorites tonight, with the point spread sitting at just over a touchdown. Tune in and join us in the comments to follow along with this big NFC matchup.
Carolina Panthers (6-5) vs. San Francisco 49ers (7-4)
Levi’s Stadium
Santa Clara, California
Monday, November 24, 2025
5:15 PM Pacific Time (7:15 PM Central)
TV Channel: ESPN
Commentators: Joe Buck, Troy Aikman
Online Streaming: ESPN app, NFL+
Point spread: 49ers -7.5
Over/under total: 49.5
2022 Week 5: 49ers 37, @Panthers 15
Regular season: Panthers lead 13-9-0
Postseason: 49ers lead 1-0 (2013 Divisional Round)
Current win streak: 49ers 2