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Chelsea moved up to second in the Premier League over the weekend and will look to take their impressive domestic form onto the European stage when Barcelona visit Stamford Bridge.
A 2-0 win at Burnley made it five Premier League victories out of six for Enzo Maresca's side, who are six points behind Arsenal and face the leaders next.
It makes for a mouthwatering week, with Barcelona up next.
The two clubs have shared several memorable Champions League encounters over the years, most notably their semifinal meeting in 2012 when the Blues went on to lift the trophy for the first time.
Chelsea have beaten Ajax and Benfica in their two league phase home games this term. They're level on seven points with Barca, who shared a chaotic 3-3 draw with Club Brugge last time out.
MORE:How Chelsea beat a Tottenham side so bad they were booed off the pitch
Chelsea lineup vs. Barcelona: Predicted starting XI
Formation: 4-2-3-1
Sanchez (GK)
Gusto, Adarabioyo, Chalobah, Cucurella
James, Caicedo
Neto, Fernandez, Estevao
Joao Pedro
Chelsea team news
Reece James was substituted at halftime against Burnley, but Maresca confirmed this change was pre-planned and not a return of the captain's injury woes. James could start in midfield alongside Moises Caicedo, with Malo Gusto at right-back.
Wesley Fofana will return to the matchday squad after being omitted as a precaution, but Tosin Adarabiyo could keep his place after impressing at the weekend.
Maresca has an enviable array of options in attack and must decide whether to start Estevao and set off a mouthwatering face-off with Barcelona's teenage superstar Lamine Yamal.
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Chelsea injury list
Below is the latest injury picture for Chelsea, including estimated return dates for those who are sidelined.
Romeo Lavia
Injury: Thigh muscle injury
Expected return date: December 2025
Lavia has a muscle issue that will almost certainly see him out of action until some time after the November international break. Maresca hopes the injury is not serious, but a return in December at the earliest is the optimistic view.
Cole Palmer
Injury: Groin/toe
Expected return date: December 2025
Maresca was forced to admit his mistake over talisman Palmer's return after he missed out on England duty earlier this month.
Initial estimates over his groin problem were increased to "at least six weeks" and he will not come back into the squad until December. Palmer's absence has been compounded and lengthened by him suffering a broken toe in an accident at home.
Dario Essugo
Injury: Thigh injury
Expected return date: December 2025
Essugo arrived at Chelsea carrying a thigh injury following his loan return to Sporting CP from Las Palmas.
While there has been little confirmed reporting on his return, there has been recent speculation that he might be out until December or even into early 2026.
Levi Colwill
Injury: Anterior cruciate ligament (ACL) tear
Expected return date: June 2026
Colwill suffered an ACL tear in preseason and will miss the full campaign. The England international is still in the early stages of his rehabilitation.
Mykhailo Mudryk
Suspension: Doping
Expected return date: Unknown
Ukraine international Mudryk has not been available for selection since December 2024 after failing a doping test.
Chelsea vs. Barcelona match details
Date: Tuesday, November 24, 2025
Kickoff time: 8 p.m. local
Location: Stamford Bridge (London, UK)
Competition: Champions League (league phase, matchweek 5)
Referee: Slavko Vincic (Slovenia)
VAR: Christian Dingert (Germany)
Chelsea news and related links