Gaffer: Mikel Arteta celebrated six years as Arsenal boss last weekend
Arsenal Football Newsletter
The Gunners host Oliver Glasner's side on Tuesday night knowing victory would earn them a two-legged semi-final showdown with Chelsea.
Rotation is expected from Palace, with this their third match in five days, and Arteta is also set to use his squad.
Gabriel Jesus could be handed his first start since January, after the Arsenal boss confirmed the striker is ready to start.
"Yes, he is," Arteta said.
"You can see now, not only in games, every day in training how much he wants it. He's going to deserve a chance soon."
Noni Madueke is set to come into the side if Bukayo Saka is handed a rest, while Eberechi Eze could also feature from the start against his former club.
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There is a big decision to make in midfield for Arteta. Martin Zubimendi has played a lot of football this season and is about to experience his first winter period without a break.
Declan Rice has also been near enough an ever-present in the side, and Christian Norgaard could therefore come in for a rare start.
Kepa Arrizabalaga can expect to continue as the cup goalkeeper, but there are limited options for rotation in defence.
Myles Lewis-Skelly is likely to come in at left-back, but injuries to Ben White, Cristhian Mosquera and Gabriel mean Arteta might have to go stronger than he would otherwise like.
There could be minutes for 16-year-old defender Marli Salmon, who made his debut against Club Brugge earlier this month.
However, an appearance off the bench appears more likely than the teenager being thrown into the starting lineup
Predicted Arsenal XI (4-3-3): Kepa; Timber, Saliba, Calafiori, Lewis-Skelly; Norgaard, Merino, Eze; Madueke, Jesus, Martinelli
Injured: Gabriel, White, Mosquera, Dowman, Havertz
Time and date: 8pm GMT on Tuesday, December 23, 2025
Venue: Emirates Stadium
How to watch: Sky Sports/ITV