Pep Guardiola's side were without 11 senior players for their shock midweek defeat to Bodo/Glimt, with Guehi and Antoine Semenyo both ineligible to feature in the Champions League. The Blues will also welcome back Bernardo Silva after he was suspended for the 3-1 loss on Tuesday night.
City are expected to make several changes to their starting line up and Guardiola could drop some star names as he hopes to return to winning ways. The Blues know they can't afford to drop many more points if they are to keep their faint title hopes alive, and here is how we think they should line up this weekend.
Donnarumma is still the first-choice and there is no need for him to be dropped this weekend.
1. GK - Gianluigi Donnarumma
Donnarumma is still the first-choice and there is no need for him to be dropped this weekend. | Getty Images
Khusanov has played well in recent weeks and is the obvious choice at centre-back.
2. CB - Abdukodir Khusanov
Khusanov has played well in recent weeks and is the obvious choice at centre-back. | Getty Images
Guehi should make his debut and there is no reason why he shouldn't start the match.
3. CB - Marc Guehi
Guehi should make his debut and there is no reason why he shouldn't start the match. | Getty Images
Lewis is the sensible choice to start at right-back even if Nunes is back in the squad.
4. RB - Rico Lewis
Lewis is the sensible choice to start at right-back even if Nunes is back in the squad. | Getty Images