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Viktor Gyokeres opened the scoring inside two minutes, before Riccardo Calafiori was adjudged by VAR to have felled Jorginho just four minutes later.
The winger dusted himself down to convert the penalty - just the third goal Mikel Arteta’s side have conceded all season on the continent - but the hosts were ahead not long after as Kai Havertz, starting his first match in a year following a lengthy injury lay-off, lashed home. Gabriel Martinelli tapped home as Havertz turned provider for number three.
A lapse in concentration at the back late on allowed substitute Ricardinho to nod in a consolation for Kairat, but it did not affect the result, with the north London club earning an eighth win out of eight in the Champions League, sailing into the knockout stages as table-toppers.
More to follow.