Guimaraes missed last Sunday’s 2-0 defeat at home to Aston Villa due to an ankle injury but was named on the bench for the 1-1 draw against Paris Saint-Germain on Wednesday night.
The Magpies’ skipper wasn’t quite ready to make his return, instead acting as a vocal support to his teammates, but it is hoped he can take to the pitch at Anfield.
Asked about Guimaraes’ fitness and availability, Eddie Howe said: “Slightly unknown at the moment. I'd say he did really well to be with us in Paris. I think that's more down to the fact that he was desperate to be there and support the players.
“We did very, very light training and he participated in that, but it was next to nothing, to be honest. He trained with us yesterday, but that was more of a test.
“So, let's see how he is today. This will be the day, really, where we decide.”
Howe changed his formation to 5-4-1 in Paris and could stick with it as Newcastle look to claim their first victory at Anfield in 32 years.
Here’s how Newcastle United are predicted to line-up: