Arsenal Football Newsletter
Gyokeres scored twice off the bench against Sunderland at the weekend and is rewarded by getting the nod at the Gtech Community Stadium.
Kai Havertz, meanwhile, has suffered a muscular injury, which could see him miss another extended period after he recently returned from a long-term knee problem.
The German had performed superbly on his return to action, but misses out tonight and is set to be sidelined for the FA Cup tie with Wigan and the Premier League encounters against Wolves and Tottenham.
Bukayo Saka is back in the squad after overcoming a hip injury and there is also a return for Martin Odegaard.
The Arsenal captain has missed wins over Chelsea and Sunderland with a minor muscle issue, and Mikel Arteta was coy on the fitness of Odegaard and Leandro Trossard at his press conference on Wednesday.
Trossard was forced off late against Sunderland.
“We will see with the medical team,” said Arteta when asked about injuries.
Pushed on Odegaard being out and a timeframe for his return, the Arsenal boss said: “I didn't say that”.
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The likes of Declan Rice and Martin Zubimendi will need to be rested at some point, but Arsenal host Wigan in the FA Cup this weekend, and so changes are expected to happen then rather than against Brentford.
There is rotation in defence as Piero Hincapie replaces Riccardo Calafiori, who struggled on Saturday in what was his first Premier League start since December.
Meanwhile, William Saliba misses out and his place is taken by Cristhian Mosquera.
Max Dowman is closing in on his Arsenal comeback but this game will come to soon for the 16-year-old.
Confirmed team news
Arsenal XI: Raya, Timber, Mosquera, Gabriel, Hincapie, Rice, Zubimendi, Madueke, Eze, Trossard, Gyokeres.
Substitutes: Arrizabalaga, White, Calafiori, Lewis-Skelly, Norgaard, Odegaard, Martinelli, Saka, Jesus.