Arsenal will visit League One side Mansfield Town, while Manchester City travel to Newcastle United in a mouth-watering all-Premier League tie following the FA Cup fifth-round draw on Monday.
Third-tier Mansfield stunned top-flight strugglers Burnley 2-1 at Turf Moor on Saturday and have been rewarded with a clash against 14-time winners and Premier League leaders Arsenal.
Pep Guardiola’s City face Newcastle in a repeat of one of this season’s League Cup semi-finals, while Premier League bottom side Wolverhampton Wanderers host Liverpool.
Brentford head to West Ham United after an own goal away to sixth-tier Macclesfield — who stunned holders Crystal Palace in the last round — gave them a 1-0 win on Monday.
Championship side Wrexham welcome eight-time winners Chelsea, while Fulham entertain Southampton and Leeds United host fellow second-tier side Norwich City.
Sunderland face a second successive away trip after being drawn against Port Vale or Bristol City, whose fourth-round tie has been postponed until March 3 due to a waterlogged pitch.
**FA Cup fifth-round draw**
* Fulham v Southampton
* Port Vale or Bristol City v Sunderland
* Newcastle United v Manchester City
* Leeds United v Norwich City
* Mansfield Town v Arsenal
* Wolverhampton Wanderers v Liverpool
* Wrexham v Chelsea
* West Ham United v Brentford
Matches will be played over the weekend of March 7–8.