Arsenal make two changes after that disastrous draw at Wolves in midweek.
Eberechi Eze comes into midfield, with Leandro Trossard also in the starting XI.
Noni Madueke and Gabriel Martinelli drop to the bench.
**(4-2-3-1)**: Raya; Timber, Saliba, Gabriel, Hincapie; Rice, Zubimendi; Saka, Eze, Trossard; Gyokeres
**SUBS**: Kepa, Mosquera, Odegaard, Jesus, Martinelli, Norgaard, Madueke, Calafiori, Lewis-Skelly
It seems an age since Thomas Frank's final game in charge almost two weeks ago when Tottenham were beaten 2-1 at home by Newcastle.
Igor Tudor makes two changes in his first match as Randal Kolo Muani and Joao Palhinha replace the injured Wilson Odobert and Dominic Solanke, who drops to the bench.
**(4-3-3)**: Vicario; Gray, Dragusin, van de Ven, Spence; Bissouma, Palhinha, Gallagher; Sarr, Kolo Muani, Simons
**SUBS**: Austin, Richarlison, Tel, Solanke, Souza, Wilson, Olusesi, Williams-Barnett, Rowsell
The North London Derby is never quiet, but few in recent years have had as much significance as this one.
On the one hand, Igor Tudor takes charge of his first game as manager of Tottenham as he attempts to take them away from relegation trouble - a statement that would have seemed ridiculous to write at the start of the season.
For Arsenal this match could be pivotal in their title push after the Gunners' lead at the top of the table was cut to just two points following Man City's win over Newcastle on Saturday.
After drawing to Brentford and Wolves over the past 10 days, the pressure is on Mikel Arteta's men.
And welcome to Daily Mail Sport's live blog of Tottenham's huge Premier League clash against Arsenal.
Be sure to stay with us throughout the afternoon for all the build-up, team news and live updates from the Tottenham Hotspur Stadium.
Key Updates
* Arsenal TEAM NEWS
* Tottenham TEAM NEWS
* A huge afternoon in store
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