The Sea Eagles will be looking to dust off their feathers and regroup following their one-point loss to the Raiders, taking on Round 1 winners the Knights.
Manly started well with their new-look side without long-term halfback and captain Daly Cherry-Evans, racing out to a 14-6 lead by halftime.
However, they could not maintain their composure, allowing Canberra back into the match which was pushed into golden point extra time, with rookie Raiders halfback slotting the winning field goal.
Under new coach Justin Holbrook, the Knights started their season with a bang, taking the two points over the Cowboys in Las Vegas.
The victory was their first since Round 16 last year - but did come at a cost with five-eighth Fletcher Sharpe sustaining a knee injury set to keep him out until Round 3.
However Star recruit Sandon Smith was able to step up in the match played a leading role in guiding the side to the ground-breaking win.
Team News
Sea Eagles: Broncos premiership winner Kobe Hetherington will start at prop with Siosiua Taukeiaho nursing a calf injury. After playing one NRL game at Newcastle last year, prop Paul Bryan is set for his club debut off the bench. Young gun Joey Walsh has again been named in the No.14 as he chases a second NRL appearance. Brandon Wakeham and Josh Feledy round out the extended bench.
Knights: Sandon Smith takes over in the No.6 jersey with Fletcher Sharpe facing another week on the sidelines with a knee injury. Back-rower Francis Manuleleua has been added to the bench and is line for his NRL debut. Tyson Frizell is named to start at lock but may swap with Mat Croker on game day as he did in Las Vegas.
Stat Attack
The Sea Eagles have won only one of their past four games against Newcastle.
The Knights have won only four of 23 games at 4 Pines Park.
Sea Eagles centre Tolu Koula has scored a try in 10 consecutive games at 4 Pines Park.
Knights winger Greg Marzhew has scored six tries in seven games against the Sea Eagles.
Sea Eagles second-rower Haumole Olakau’atu has scored five tries in his last six games against the Knights.
Stats supplied by David Middleton, League Information Services, author of the official annual of the NRL.