Pep Guardiola's side were thrashed 3-0 in the Spanish capital a week ago and know they must produce a monumental comeback if they are to remain in the competition. The Blues were held to a 1-1 draw by West Ham in the Premier League at the weekend, which sparked concerns of the season falling flat on all fronts.
City will do everything they can to beat Madrid in midweek, but also face Arsenal in the League Cup final this weekend. It will be fascinating to see which side Guardiola picks on Tuesday night and here is how we think City should line up.
Donnarumma struggled in the first leg but will keep his place against Madrid.
1. GK - Gianluigi Donnarumma
Donnarumma struggled in the first leg but will keep his place against Madrid. | Getty Images
Nunes was missed in Madrid and should return at right-back.
2. RB - Matheus Nunes
Nunes was missed in Madrid and should return at right-back. | Getty Images
Dias was rested against West Ham and should be fit to face Madrid.
3. CB - Ruben Dias
Dias was rested against West Ham and should be fit to face Madrid. | Getty Images
Guehi is already a mainstay in the City backline and should start.
4. CB - Marc Guehi
Guehi is already a mainstay in the City backline and should start. | Getty Images