The Magpies started well, with Dan Burn testing goalkeeper Joan García with a shot on the turn from Malick Thiaw's knock-down, but in the sixth minute the hosts took the lead.
Brazilian winger Rafinha's finish was crisp and calm, but there was a touch of fortune about the build-up as Lewis Hall slipped as he looked to intercept a through ball from Lamine Yamal, who himself had profited from a Thiaw slip. Hall regained his footing, but couldn't cut out Fermín López's pass and Rafinha put his side 2-1 up on aggregate.
**Newcastle United:** Aaron Ramsdale, Kieran Trippier (c), Lewis Hall, Joelinton, Sandro Tonali, Anthony Gordon, Harvey Barnes, Malick Thiaw, Anthony Elanga, Dan Burn, Jacob Ramsey
**Subs not used:** Nick Pope, John Ruddy, Aidan Harris, Sven Botman, Yoane Wissa, Will Osula, Tino Livramento, Jacob Murphy, Nick Woltemade, Joe Willock, Alex Murphy, Sean Neave