Vying for a precious FA Cup semi-final spot at Wembley, Southampton and Arsenal lock horns at St Mary's Stadium in Saturday evening's quarter-final battle.
The Saints progressed past Fulham 1-0 to reach the last eight, while the Gunners made hard work of a 2-1 win at Mansfield Town, and here Sports Mole rounds up the team news for both sides.
SOUTHAMPTON
Out: Mads Roerslev (knee), Flynn Downes (suspended), Kuryu Matsuki (suspended), Alex McCarthy (wrist)
Doubtful: Welington (muscle), Jay Robinson (thigh), Leo Scienza (groin), Jack Stephens (unspecified)
Sports Mole's predicted XI: Peretz; Bree, Wood, Harwood-Bellis, Manning; Charles, Romeu; Fellows, Azaz, Edozie; Stewart
ARSENAL
Out: Mikel Merino (foot), Eberechi Eze (calf), Noni Madueke (knee), Piero Hincapie (unspecified)
Doubtful: Martin Zubimendi (knee), Declan Rice (unspecified), Bukayo Saka (unspecified), Leandro Trossard (hip), William Saliba (ankle), Gabriel Magalhaes (knee), Jurrien Timber (unspecified)
Sports Mole's predicted XI: Kepa; White, Salmon, Mosquera, Calafiori; Havertz, Norgaard, Lewis-Skelly; Dowman, Gyokeres, Jesus