The Magpies boss has shuffled his pack as they look to damage the Gunners' title hopes, with Nick Pope, Dan Burn, Lewis Miley, Joe Willock, Jacob Murphy and captain Bruno Guimarães - who starts for the first time since February - all restored to the line-up.
That means goalkeeper Aaron Ramsdale reverts to the bench, with Lewis Hall, Harvey Barnes and Anthony Elanga also making way and named among the substitutes at the Emirates Stadium.
Tino Livramento, meanwhile, misses out through injury.
Six players who started last weekend's defeat to Bournemouth keep their places - Sven Botman, Sandro Tonali, Malick Thiaw, Will Osula and Jacob Ramsey.
There is plenty of firepower on the United bench, with Yoane Wissa, Nick Woltemade, Barnes and Elanga all included alongside Ramsdale and Hall.
Kieran Trippier, Alex Murphy and Sean Neave complete the list of substitutes available to Howe against Mikel Arteta's men.
**Newcastle United:** Nick Pope, Sven Botman, Sandro Tonali, Malick Thiaw, Will Osula, Jacob Murphy, Joe Willock, Dan Burn, Bruno Guimarães (c), Jacob Ramsey, Lewis Miley
**Substitutes:** Aaron Ramsdale, Kieran Trippier, Lewis Hall, Yoane Wissa, Harvey Barnes, Anthony Elanga, Nick Woltemade, Alex Murphy, Sean Neave