Liverpool have arrived at Old Trafford without Isak, who is reported to have suffered a groin injury in training.
Freddie Woodman starts again with Alisson still out, with the third-choice goalkeeper trusted for one of the biggest games of his career.
A number of youngsters have made the bench including, for a second time, 18-year-old striker Will Wright as well as January centre-back signing Mor Talla Ndiaye.
Liverpool: Woodman; Jones, Konate, Van Dijk, Robertson; Gravenberch, Mac Allister; Frimpong, Szoboszlai, Wirtz; Gakpo
Substitutes: Pecsi, Ndiaye, Gomez, Kerkez, Nyoni, Morrison, Ngumoha, Chiesa, Wright
Man United: Lammens; Dalot, Maguire, Heaven, Shaw; Casemiro, Mainoo; Mbeumo, Fernandes, Cunha; Sesko
Substitutes: Bayindir, Yoro, Dorgu, Malacia, Mazraoui, Mount, Ugarte, Amad, Zirkzee
Man United vs. Liverpool is being shown live on Sky Sports Main Event and Sky Sports Premier League in the UK, which are available to live stream with Sky Sports here.
Live audio commentary of Man United vs. Liverpool and a full match replay and highlights will also be available on All Red Video here.
This Is Anfield will also be providing live text commentary throughout on our website and full match reaction and analysis on the This Is Anfield app for iPhone and Android later.