Mamardashvili is back in goal after missing the last two games, seeing Freddie Woodman return to the bench with Alisson still sidelined.
There is no Florian Wirtz in the squad after he battled with illness during the week.
Liverpool: Mamardashvili; Jones, Konate, Van Dijk, Kerkez; Gravenberch, Mac Allister; Frimpong, Szoboszlai, Ngumoha; Gakpo
Substitutes: Woodman, Gomez, Ndiaye, Robertson, Nyoni, Morrison, Wright, Chiesa, Isak
Chelsea: Jorgensen; Gusto, Fofana, Colwill, Cucurella, Hato; Caicedo, Santos, Enzo; Palmer, Pedro
Substitutes: Slonina, James, Acheampong, Tosin, Chalobah, Lavia, Eboue, Kavuma-McQueen, Delap
Liverpool vs. Chelsea is being shown live on TNT Sports 1 in the UK, which is available to live stream with HBO Max here.
Live audio commentary of Liverpool vs. Chelsea and a full match replay and highlights will also be available on All Red Video here.
This Is Anfield will also be providing live text commentary throughout on our website and full match reaction and analysis on the This Is Anfield app for iPhone and Android later.