The NFL will release the full 2026 schedule Thursday night, but they are releasing certain marquee matchups ahead of time and one of those is Detroit's Week 2 game.
The Lions will travel to Buffalo to take on the Bills and MVP quarterback Josh Allen in brand new Highmark Stadium on a national stage Week 2 on Thursday Night Football (Amazon Prime Video) Sept. 17.
The last time these two teams squared off was an epic back-and-forth battle at Ford Field Dec. 15, 2024 where the Bills defeated Detroit, 48-42. It was one of only two regular season games the Lions lost that season on way to a 15-2 record and the No. 1 seed in the NFC playoffs.