AFC Bournemouth need to just avoid defeat to confirm their place in European competition tonight, with that one point enough to secure a top seven finish.
A win would guarantee a top six finish and would leave them in the hunt for the Champions League going into the final day.
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Iraola reflected on his time with the Cherries, but said a positive result, particularly against a side of the calibre of City, would top it all.
“I think we've had such great memories these three seasons,” Iraola said.
(Image: Richard Crease)
“I can tell you, I don't know, 10, 12 games straight away that come to my mind, especially against the big clubs, and we've had them at home, away.
“But I think tomorrow can be probably the biggest one, no? Because there is a reward there waiting for us.
“And then the difficulty also of the challenge makes it like even more special. We know you have to be really, really good, excellent, I would say, to get something against City in these circumstances.
“And in case that you get it, I think it would be probably the biggest one.”
(Image: Richard Crease)
Iraola admitted it could be an emotional night, with the game marking his final home game as Cherries boss, before he leaves in the summer.
But the boss said he’s not thinking about that right now: “Probably after the game could be emotional. Yes, definitely.
“The thing is, right now I'm not thinking on those things because the challenge of the game is so big.
“We focus on how we can hurt Man City, how we can stop them, thinking all the possible options we have, all the things that they can do.
“And there are so many things going in your head that probably you are not focusing on the things that are like of the football game.”