Enzo Maresca faces his first Manchester derby as his men in blue face a tricky test against Michael Carrick and co at Old Trafford on Sunday evening.
Elliot Anderson starts in his first Manchester derby since joining City from Nottingham Forest in June.
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City enter the 199th Manchester derby looking to extend their perfect start to the season to five wins from five across all competitions.
Maresca's side have beaten Bournemouth, Crystal Palace and Coventry City in their three opening league fixtures before registering a 2-0 win against FC Porto in the Champions League on Tuesday night - a result that saw Erling Haaland become the club's third-highest goalscorer of all time with 167 goals.
Nico O'Reilly is fit and available after the back issue that kept him out of the starting XI against Coventry City, with Maresca confirming the England international is "100 percent" ready.
Jeremy Doku remains absent for the trip across town, having missed every competitive fixture this season after suffering a calf injury in August's 3-0 Community Shield defeat to Arsenal. Maresca confirmed in Friday's press conference that the Belgian needs "some more days" before returning to contention.
Antoine Semenyo starts in Doku's continued absence, with the Ghana international having formed a strong partnership with Haaland in the opening weeks of the campaign.
After an important victory over FC Porto in midweek, Manchester City now prepare for one of the most significant occasions in the footballing calendar, the Manchester derby, as they travel the short distance to Old Trafford to face off against Manchester United on Sunday.cityxtra.co.ukMan Utd vs Man City (Premier League): Match Preview, Team News, Head to Head, How to Watch
After an important victory over FC Porto in midweek, Manchester City now prepare for one of the most significant occasions in the footballing calendar, the Manchester derby, as they travel the short distance to Old Trafford to face off against Manchester United on Sunday.
Marc Guehi and Ruben Dias continue at centre-back after managing clean sheets in their most recent two outings. The pair will be tested by a Manchester United attack that Maresca has identified as the most direct in the Premier League, with the Red Devils playing more balls in behind than any other side in the division this season.
City were beaten 2-0 in this fixture last season Michael Carrick's first game back in charge following the sacking of Ruben Amorim. Michael Oliver will officiate Sunday's fixture; City have lost just twice in their last 10 Premier League games officiated by Oliver.
Ahead of Sunday's 16:30 UK kick-off at Old Trafford, here are the confirmed line-ups for the first Manchester derby of the Maresca era.
Manchester United
Starting XI: Lammens; Dalot, Maguire, Martinez, Dorgu; Tielemans, Mainoo; Mbeumo, Fernandes, Rashford; Cunha
Substitutes: Darlow, Heaven, Mazraoui, Yoro, Mount, Santos, Lacey, Sesko, Zirkzee
Manchester City
Starting XI: Donnarumma; Nunes, Dias, Guehi, Gvardiol; Anderson, Fernandez; Foden, Cherki, Semenyo; Haaland
Substitutes: Rulli, Ndiaye, Kovacic, Reis, Bouaddi, O'Reilly, Allan, Khusanov, Lewis