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NFL Sunday Night Football best bets Week 2

NFL: Indianapolis Colts at Kansas City Chiefs

Nov 23, 2025; Kansas City, Missouri, USA; Kansas City Chiefs wide receiver Rashee Rice (4) runs against the Indianapolis Colts in overtime at GEHA Field at Arrowhead Stadium. Mandatory Credit: Denny Medley-Imagn Images Credit: IMAGN IMAGES via Reuters Connect (Reuters)

Sunday Night Football brings the Indianapolis Colts to Arrowhead to face the Kansas City Chiefs, and there are several player props worth targeting. Here are four bets for the Week 2 NFL matchup.

MORE: Bold predictions for Week 2 of 2026 NFL season

Patrick Mahomes over 211.5 passing yards

NFL: Denver Broncos at Kansas City Chiefs

Sep 14, 2026; Kansas City, Missouri, USA; Kansas City Chiefs quarterback Patrick Mahomes (15) reacts before the game at GEHA Field at Arrowhead Stadium. Mandatory Credit: Jay Biggerstaff-Imagn Images Credit: IMAGN IMAGES via Reuters Connect (Reuters)

Patrick Mahomes threw for just 184 yards in Week 1, but this is a much more favorable matchup. Indianapolis surrendered 41 points and 506 total yards to Baltimore in the opener. Mahomes also has a low number to clear at 211.5 yards.

If Kansas City is forced to throw more than it did against Denver, Mahomes should have enough volume to surpass this total.

Alec Pierce over 44.5 receiving yards

NFL: Indianapolis Colts at Houston Texans

Jan 4, 2026; Houston, Texas, USA; Indianapolis Colts wide receiver Alec Pierce (14) catches a touchdown pass against the Houston Texans during the first half at NRG Stadium. Mandatory Credit: Thomas Shea-Imagn Images Credit: IMAGN IMAGES via Reuters Connect (Reuters)

Alec Pierce opened the season with four catches for 61 yards, showing that he can make an impact as a big-play threat.

The concern heading into Sunday was his heel, but Pierce returned to full practice Friday and carries no game designation. Indianapolis could also be forced into a pass-heavy game script against Kansas City, giving Pierce opportunities to clear 44.5 yards.

MORE: Predicting NFL upsets in Week 2 of 2026 season

Rashee Rice over 49.5 receiving yards

NFL: Kansas City Chiefs Training Camp

Jul 29, 2026; St. Joseph, MO, USA; Kansas City Chiefs wide receiver Rashee Rice (4) walks down the hill to the practice fields during training camp at Missouri Western State University. Mandatory Credit: Denny Medley-Imagn Images Credit: IMAGN IMAGES via Reuters Connect (Reuters)

Rashee Rice had a quiet Week 1 with only two catches for 19 yards, but this is an excellent bounce-back spot. Indianapolis allowed Zay Flowers to explode for 150 yards before his injury in Week 1, while Rice is now facing a much softer matchup than the Denver defense he saw Monday.

Rice also practiced fully all week and is good to go.

Tyler Warren over 42.5 receiving yards

Jan 4, 2026; Houston, Texas, USA; Indianapolis Colts tight end Tyler Warren (84) makes the catch against the Houston Texans during the first half at NRG Stadium. Mandatory Credit: Thomas Shea-Imagn Images

Tyler Warren caught five passes for 45 yards against Kansas City in his previous meeting with the Chiefs, already giving him a strong track record against this opponent.

Indianapolis may have to throw frequently if Kansas City builds an early lead, creating additional opportunities for Warren.

****Game odds refresh periodically and are subject to change. If you or someone you know has a gambling problem and wants help, call 1-800-GAMBLER.****

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