San Francisco 49ers defensive end [Nick Bosa](/players/nick-bosa) is expected to miss multiple weeks after suffering a calf injury in practice this week, NFL Network Insider Ian Rapoport and ESPN's Adam Schefter reported on Friday.
Bosa will be sidelined for [Sunday's game](https://www.nfl.com/games/cardinals-at-49ers-2026-reg-3?tab=overview) against the Arizona Cardinals. It remains to be seen if he will be placed on injured reserve, Rapoport and Schefter added.
Around the NFL will have more on Bosa's injury shortly.