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Watch: Steelers coach Mike McCarthy previews Week 5 matchup with ColtsVideo

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Steelers head coach Mike McCarthy looks on during the Browns game Thursday, Oct. 1, 2026 at Huntington Bank Field. (Chaz Palla | TribLive)

The Pittsburgh Steelers (2-2) will try to rebound from Thursday’s 27-24 loss to the Browns in Cleveland when they host the Indianapolis Colts at 1 p.m. Sunday at Acrisure Stadium.

Indianapolis (2-2) is coming off a 30-13 victory over the Washington Commanders on Sunday in London, England. Running back Jonathan Taylor ran for 95 yards and two touchdowns, and QB Daniel Jones threw for 143 yards with an interception and ran for a score.

Steelers coach Mike McCarthy is previewing the matchup during his weekly news conference with reporters.

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Steelers coach Mike McCarthy: DT Derrick Harmon (foot) is going to Injured reserve. "So he will be down for a few weeks" Jamel Dean (ankle), the prognosis is not as dire

— Chris Adamski (@C_AdamskiTrib) October 5, 2026

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