NFL: New Orleans Saints at Los Angeles Rams
Aug 22, 2026; Inglewood, California, USA; Los Angeles Rams quarterback Matthew Stafford (9) watches against the New Orleans Saints in the first half at SoFi Stadium. Mandatory Credit: Kirby Lee-Imagn Images Credit: IMAGN IMAGES via Reuters Connect (Reuters)
Week 4 of the 2026 NFL season ended with a bang on Monday night when the Atlanta Falcons torched the New Orleans Saints.
The Falcons won 45-24, bringing their record to 2-2 overall. They’ve been a completely different team since quarterback Michael Penix Jr. returned to the lineup.
Now that Week 4 is over, the Los Angeles Rams are the Super Bowl LXI favorites at +650. They did so after defeating the Philadelphia Eagles 24-20 on Sunday. They came back from multiple-score deficits to win that game.
The Buffalo Bills are right behind the Rams with +700 odds after losing to the New England Patriots on Sunday. They’re still in good shape with a 3-1 record heading into Week 5.
The Seattle Seahawks and Baltimore Ravens are behind the Rams and Bills at +850 odds, followed by the San Francisco 49ers at +950.
Updated Super Bowl 61 betting odds
NFL: Detroit Lions at Buffalo Bills
Sep 17, 2026; Orchard Park, New York, USA; Buffalo Bills quarterback Josh Allen (17) runs to score a touchdown against the Detroit Lions during the second half at New Highmark Stadium. Mandatory Credit: Gregory Fisher-Imagn Images Credit: IMAGN IMAGES via Reuters Connect (Reuters)
The Kansas City Chiefs are next with +1,000 odds after defeating the Las Vegas Raiders on Sunday. That game pitted two 3-0 teams against each other before the Chiefs gave the Raiders their first loss.
The Jacksonville Jaguars, Chicago Bears, Dallas Cowboys, and Detroit Lions round out the top 10.
These odds can and will change as we get closer to the NFL playoffs.
****Game odds refresh periodically and are subject to change. If you or someone you know has a gambling problem and wants help, call 1-800-GAMBLER.****