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Bold predictions for Monday Night Football in NFL Week 5

NFL: Detroit Lions at Buffalo Bills

Sep 17, 2026; Orchard Park, New York, USA; Buffalo Bills quarterback Josh Allen (17) runs to score a touchdown against the Detroit Lions during the second half at New Highmark Stadium. Mandatory Credit: Gregory Fisher-Imagn Images Credit: IMAGN IMAGES via Reuters Connect (Reuters)

The Buffalo Bills visit the Los Angeles Rams on **Monday Night Footbal**l this week, and the stage is set for an offensive shootout. Los Angeles enters the game 2nd in yards per game while Buffalo is 8th.

Buffalo has fared better at turning yardage into points and ranks 1st in PPG (31.8). Defensively, Los Angeles has the edge. The Rams rank 9th in points allowed per game (20.8), and the Bills are 25th (26.8). During their last meeting (2024), quarterbacks Josh Allen and Matthew Stafford stole the show.

Allen finished the game with 342 passing yards, three passing touchdowns, and three rushing touchdowns. His performance overshadowed Stafford’s 320 passing yards and two touchdowns.

Heading into Monday night’s Bills/Rams showdown, here are four bold predictions.

Josh Allen and Matthew Stafford combine for more than 600 yards passing

NFL: Arizona Cardinals at Los Angeles Rams

Los Angeles Rams quarterback Matthew Stafford (9). Credit: Gary A. Vasquez-Imagn Images.

The probability of either quarterback failing to shine is low. Allen and Stafford are the catalysts of their respective offenses. The highly contested showdown will see the quarterbacks trade blows throughout the night. Opposing quarterbacks have exploited Buffalo’s defense through four weeks, and the ’85 Chicago Bears/’00 Baltimore Ravens would struggle to contain Josh Allen.

Prediction: The quarterbacks shine in primetime, combining for over 600 yards through the air.

Kyren Williams will have a two-touchdown night

NFL: NFC Championship Game-Los Angeles Rams at Seattle Seahawks

Jan 25, 2026; Seattle, WA, USA; Los Angeles Rams running back Kyren Williams (23) runs to score a touchdown against the Seattle Seahawks during the first half in the 2026 NFC Championship Game at Lumen Field. Mandatory Credit: Kevin Ng-Imagn Images Credit: IMAGN IMAGES via Reuters Connect (Reuters)

The Bills defense is struggling and is worse at defending the run. Kyren Williams and Blake Corum will have success, but Williams will see his number called at the goal line. In a second consecutive high-scoring meeting, Williams will match his 2024 production and make two trips to the end zone.

Prediction: Los Angeles running back Kyren Williams will have success against a Buffalo defense that cannot contain opposing running backs. The veteran will record two rushing touchdowns for a second consecutive game.

Monday Night Football will end with zero recorded sacks

NFL: Buffalo Bills at Houston Texans

Sep 13, 2026; Houston, Texas, USA; Buffalo Bills quarterback Josh Allen (17) on the sideline before the game against the Houston Texans at Reliant Stadium. Mandatory Credit: Troy Taormina-Imagn Images Credit: IMAGN IMAGES via Reuters Connect (Reuters)

Buffalo’s defense has fared better than Los Angeles’ at reaching opposing quarterbacks, but both teams’ offensive lines will keep their quarterbacks upright. During the first four weeks of the season, both offensive lines have excelled at protecting their respective quarterbacks. They will be at the top of their game on Monday night, preventing defenders from applying pressure behind the line of scrimmage.

Prediction: The Bills and Rams put 40 points on the scoreboard, and each team’s offensive line protects their quarterbacks. Monday Night Football finishes with neither Josh Allen nor Matthew Stafford falling victim to a quarterback sack.

Monday Night Football will end with a score of 45-42

NFL: London Games-Los Angeles Rams at Jacksonville Jaguars

Oct 19, 2025; London, United Kingdom; Los Angeles Rams quarterback Matthew Stafford (9) throws the ball against the Jacksonville Jaguars in the first half during a NFL International Series game at Wembley Stadium. Mandatory Credit: Kirby Lee-Imagn Images Credit: IMAGN IMAGES via Reuters Connect (Reuters)

This game will have a flurry of offense. The teams’ defenses will struggle mightily to prevent the opposing offenses from adding points to the scoreboard. Josh Allen and Matthew Stafford will combine for more than 600 yards passing; there will be a combined eight passing touchdowns and four rushing touchdowns. The game will be decided by a game-winning field goal as time expires. The placekicker who leads his team to victory will be Tyler Bass of the Buffalo Bills.

Prediction: Monday night’s showdown will not disappoint from an offensive standpoint. The Bills and Rams will score six touchdowns each, and the Bills will secure the victory on a game-winning field goal as time expires.

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