The final game of Week 5 will be a Monday Night Football matchup featuring the Buffalo Bills (3-1) on the road against the Los Angeles Rams (2-2).
The Bills lead the all-time series between these teams, 9-6, and have won three of their four most recent meetings. However, when they last faced off, back in 2024, the Rams got a win at home in Los Angeles, 44-42.
BGN’s Brandon Lee Gowton explained why it’s easy to root for the Bills this week:
“BUFFALO BILLS at LOS ANGELES RAMS: AFC team over NFC team. **Root for the Bills.**“
Here’s everything you need to know about tonight’s game.
Buffalo Bills vs. Los Angeles Rams
TV Schedule
Game time: 8:15 PM EST
Channel: ESPN | ABC
Date: Monday, October 12, 2026
Location: SoFi Stadium | Inglewood, CA
Announcers: Joe Buck, Troy Aikman, Lisa Salters (field reporter), Laura Rutledge (field reporter)
Online Streaming
ESPN+ | FuboTV
Odds via FanDuel
Odds courtesy of FanDuel
Buffalo Bills: +3.5 (-152)
Los Angeles Rams: -3.5 (-180)
Over/under: 54.5 points
SB Nation Blogs
Bills: www.BuffaloRumblings.com
Rams: www.TurfShowTimes.com
Open thread: Discuss Monday night’s game in the comments below.