Brighton picked up two further injuries in their 2-0 loss to Liverpool at Anfield.
Chema Andres and Ferdi Kadioglu both hobbled off the pitch and join the likes of Japan international Kaoru Mitoma and Yankuba Minteh on the sidelines.
It's a blow for Brighton as they embark of a hectic fixture schedule and juggle the demands of the Premier League, the Conference League and the domestics cups.
Third place Brighton travel to Manchester City thi Wednesday for a fourth round Carabao Cup tie and they are swiftly back at the Etihad for a Premier League clash this Saturday. Next Thursday they jet to Madrid for a Conference League fixture against Getafe.
Brighton injury list in full
Kaoru Mitoma: The Japan international has been sidelined for the entire campaign so far after injurying his hamstring against Wolves towards the backend of last season. Mitoma missed the summer World Cup and is pushing hard for a return to full fitness.
Head coach Fabian Hurzeler advised that Brighton will not rush him back and the German - speaking ahead of the win against Crsytal Palace - said that after the next international break is a realistic target. Brighton’s first match after the next break is at Hull City on November 22.
Yankuba Minteh: Hurzeler stated last week that Minteh was close to being available for last Sunday’s win against Crystal Palace. Minteh though missed that match and Sunday’s 2-0 loss to Liverpool also arrived too soon.
The double header against Manchester City is now a target for the Gambian flyer.
Mats Wieffer: The Dutch full back is nearing a return from a knee injury sustained in the 4-3 loss at Chelsea earlier this season. Liverpool last Sunday proved too soon but Brighton will be keen to get him back especially after Kadioglu’s injury at Liverpool. He could be an option to face Man City.
Femi Azeez: Hurzeler said the deadline day arrival from Millwall is "getting closer" and could get his first minutes for the club "very soon". The winger maybe an option for the Eithad.
Pascal Struijk: The £18m arrival from Leeds has a thigh injury and missed the win against Palace and the loss to Liverpool. He remains a doubt for City with Hurzeler stating “It’s an injury that could get worse.”
Zadok Yohanna: The Nigerian winger builds up his fitness following his summer arrival and the £22m man could be an option after the international break.