The Blues' most recent Premier League victory came in a 2-0 win at Everton, but their progress was checked by a 2-0 home loss to Tottenham Hotspur last weekend - only their second league defeat at home to Spurs since 1990.
That was followed by a penalty-shootout exit to Liverpool in the Carabao Cup on Wednesday.
United, meanwhile, were thrashed 3-0 by Bournemouth at Old Trafford, piling further pressure on head coach Michael Carrick.
Xabi Alonso's side will be eager to rediscover their attacking rhythm and make home advantage count against their beleaguered visitors.
Cole Palmer’s availability will provide a boost, with the playmaker having served his one-match suspension for his red card against Spurs in Wednesday’s Carabao Cup tie at Anfield.
The spotlight remains firmly on Carrick amid growing speculation about his future. United’s defeat to Bournemouth extended their winless run across all competitions to eight matches and left them 16th in the Premier League, just one point above the relegation zone.
Attention will also be on whether Bruno Fernandes returns to the United starting XI after being an unused substitute against Bournemouth.
Chelsea need to show that the defeat to Spurs was only a temporary setback, while United are desperate for a result to ease the pressure surrounding Carrick and their league position.
Chelsea take on Manchester United at Stamford Bridge on Saturday, October 31.
Kick off is at 12:30 UK time. Live coverage with TNT Sports 1 and TNT Sports Ultimate on HBO Max starts at 11:00.
Chelsea v Manchester United will be live with TNT Sports 1 and TNT Sports Ultimate on HBO Max.
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