The visit of Southampton in the league precedes the second leg of Liverpool’s Champions League last-16 tie with PSG on Tuesday evening and the Carabao Cup final at Wembley next Sunday.
Slot was asked how the magnitude of that run of fixtures could impact his team selection.
“For me, the one against Southampton is by far the most important – not only because it’s the first one we play but it is a very, very important one for us,” he replied.
“So if, if I make the choice to play other players, that is because I think that is the biggest chance to win the game tomorrow and not because I want to rest them for the game against Paris Saint-Germain.
“So, the only way I make a change is because it’s only two days in between, and then I might feel that playing someone else is a better option, because we have many players that are of equal quality.
“But that then only has to do with us getting a bigger chance of winning the game against Southampton than it has anything to do with the Paris Saint-Germain game.”