Team news
Liverpool will continue to assess forward Cody Gakpo, who missed Wednesday's win against Paris St-Germain because of a niggling ankle issue.
Conor Bradley and Joe Gomez remain sidelined.
Southampton midfielder Adam Lallana has recovered from a hamstring problem and is available to face his former side.
Lesley Ugochukwu comes back into contention after being ineligible to face parent club Chelsea last time out, while Jan Bednarek, who missed that match through injury, is ready to return.
Taylor Harwood-Bellis made his comeback from an ankle issue as a substitute at Stamford Bridge and could reclaim a starting spot, though James Bree is ruled out after being forced off against the Blues.
Match facts
Head-to-head
Liverpool have won 11 of their last 13 Premier League games against Southampton (D1, L1).
Saints are winless in their past nine top-flight matches at Anfield (D2, L7), losing the last six by an aggregate score of 19-1.
This will be the fourth time that a Premier League fixture has taken place with one team top and the other bottom for both meetings in a single season. The other instances were Manchester United against Swindon in 1993-94 and Chelsea versus Sunderland in both 2006-06 and 2016-17.
A gap of 58 points separates these sides prior to this fixture, the biggest between any two teams meeting in the Premier League since July 2020, when Liverpool began a 2-0 win against Aston Villa with a 59-point advantage.
Liverpool
The Merseysiders are vying to keep four consecutive clean sheets for the first time under Arne Slot.
Liverpool are unbeaten in each of their last 24 Premier League games (W17, D7).
The Reds have scored at least twice in 25 of their 28 top-flight matches this season, at least 10 more than any other side.
Mohamed Salah has scored or assisted a goal in all but one of Liverpool's 13 league matches at Anfield this season, including each of the past 11.
Salah has been directly involved in 52 goals in all competitions this season, scoring 30 and assisting 22. That is the highest total of anyone playing in the top five European leagues.
Dominik Szoboszlai has been directly involved in six goals in his last 11 Premier League appearances, scoring six and assisting two.
Southampton
Southampton have lost 12 of their last 14 top-flight fixtures.
November's 1-1 draw at Brighton is the only time Saints have avoided defeat after falling behind in a league game this season.
They have dropped 20 points after taking the lead, the third-highest total in the top flight this term.
Southampton have kept just two clean sheets in the league this season, conceding three goals or more on 15 occasions.
Ivan Juric has won one and lost nine of his 10 Premier League matches, with a points per game rate of 0.3 - the lowest of any manager to oversee at least 10 games in the competition.
Related topics
Southampton
Liverpool
Premier League
Football