They also travelled to the south coast in the Carabao Cup just before Christmas, earning another hard-fought win.
Darwin Nunez and Harvey Elliott were both on target for the visitors, who advanced to the semi-finals with a 2-1 scoreline.
What they said
Southampton manager Ivan Juric
"Before the match, I'm always optimistic and then after maybe I think differently. But before the match I always see the possibility of doing something good.
"If you do some things, they [Liverpool] will find another way to beat you. If you are [in a] low block, they will find a way to beat you. I think we have to be perfect in both things – sometimes press, sometimes low block. We will see. We have to play well."
Pre-match stats
Liverpool have won 11 of their last 13 Premier League games against Southampton, with the exceptions being a 1-0 loss in January 2021 and a 4-4 draw in May 2023, both at St Mary's.
Southampton are winless in their last nine Premier League away games against the Reds (drawn two, lost seven), losing their last six visits to Anfield by an aggregate score of 19-1.
Only Jean-Philippe Mateta (64) and Jorgen Strand Larsen (58) have attempted more hold-ups in the Premier League this season than Southampton's Paul Onuachu (44). Indeed, 31 of Onuachu's have come in 2025, the most of any player in the competition since the turn of the year.
The last time Saints faced the Premier League's leaders away from home they became the first side in the competition's history to sit bottom and score three goals away from home against a team starting the day top of the table (3-3 draw at Arsenal in April 2023).