Long-read RNA sequencing of human microglia expands the catalog of mRNA isoforms in this important cell type and assists with the interpretation of genetic associations with Alzheimer’s disease and Parkinson’s disease.
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Fig. 1: Complex regulation of PLCG2 in Alzheimer’s disease.
References
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This is a summary of: Humphrey, J. et al. Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing. Nat. Genet. https://doi.org/10.1038/s41588-025-02099-0 (2025).
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Novel mRNA isoforms in human microglia refine genetic associations with neurodegeneration. Nat Genet (2025). https://doi.org/10.1038/s41588-025-02112-6
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Published:07 March 2025
DOI:https://doi.org/10.1038/s41588-025-02112-6
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