Arne Slot rotated his side at Home Park and you would expect him to do the same against Southampton this afternoon.
Their meeting with us is sandwiched between a Champions League round of 16 tie with French champions PSG, and they only have a 1-0 lead heading into the second game.
While Slot may publicly say beating Southampton is the most important thing, he will undoubtedly have an eye on Tuesday's tie at Anfield.
That is not to say he will be taking Saints lightly. You don’t win 20 of your 28 Premier League games so far this season by underestimating your opponents.
Many of us are expecting another defeat, some may even suggest a win is impossible given the recent 4-0 defeats, but the players cannot head to Merseyside with similar thoughts.
Games at Anfield are always special occasions, for players and for fans, but the team needs to make sure they do themselves justice.
People will have spent a lot of money to follow them, as they have done all season, and we cannot see another 4-0 defeat.
Plymouth beat Liverpool because of the togetherness they showed and Saints need to ensure they can replicate that brotherhood today.
Ivan Juric has been working with a patched-up defence in recent weeks, playing Joe Aribo and Welington out of position, but he has most of his options back now.
While James Bree is injured, Taylor Harwood-Bellis, Jack Stephens and Jan Bednarek are all available and ready to start the game at Anfield.
And although we have not seen the best of those players this season, Juric will be pleased to have natural options at centre-back this season, especially at free-scoring Liverpool.
Adam Lallana is also available once again and this game will be special for him no doubt, although I'm not sure how big of a role he will play.
Juric explained that Saints will need to be "perfect" to get a result against Liverpool but that is not a label you could give us at any point this season.
Sadly, we have seen little evidence that this side can achieve that, but I'm still holding onto hope that we can end the season on a positive note.
Away from the football, I was pleased to see Southampton boxers Ryan Garner and Lewie Edmondson winning in Bournemouth last weekend.
I've met Ryan at St Mary's before and have followed his career ever since with great interest. To see him win a European title is brilliant.
Ryan and Lewie are setting an example for youngsters in the local area. They are proving that people from Southampton can achieve things in sports.
It has not been an easy road for Ryan, as he admits himself, but he has some serious momentum behind him now. The support he received at the BIC was incredible.
Those wins will have boosted the chances of a boxing card at St Mary's, something I know Ryan has long dreamt about headlining.
If the powers that be can make that happen, it would be amazing and something I'm sure would draw a lot of interest from people locally.
To have a European champion from the city is no mean feet. Winning the world title at St Mary's would be incredible.
It's also nice for us to be speaking about a positive local sporting story in what has been a dreadful football season.
I'm keeping my fingers crossed that Saints can produce something today. They have had an extended period between games and that needs to be capitalised upon.