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Disrupting cholesterol homeostasis in T cells boosts antitumour responses

A new study identifies a mechanism by which Elovl1 deletion disrupts the canonical feedback inhibition of cholesterol synthesis in T cells. By fundamentally rewiring cholesterol metabolism, Elovl1-depleted T cells gain increased fitness and synergize with anti-PD-1 therapy to enhance antitumour responses.

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Fig. 1: Elovl1 deletion rewires mevalonate metabolism in T cells to increase cholesterol and enhance antitumour function.

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Authors and Affiliations

Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, USA

Kelly T. Kennewick & Steven J. Bensinger

Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA, USA

Steven J. Bensinger

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Kelly T. Kennewick

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2. Steven J. Bensinger

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Correspondence to Steven J. Bensinger.

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Kennewick, K.T., Bensinger, S.J. Disrupting cholesterol homeostasis in T cells boosts antitumour responses. Nat Metab (2025). https://doi.org/10.1038/s42255-025-01240-x

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Published:10 March 2025

DOI:https://doi.org/10.1038/s42255-025-01240-x

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