Sevilla's Chidera Ejuke scored the only goal of the game, early in the second half, to send them above Real Sociedad in the table, into 10th spot.
Alguacil made a startling eight changes to the XI on duty last week, with only Nayef Aguerd, Igor Zubeldia and Benat Turrientes retaining their place in the side.
Despite making four substitutions at the same time, there was no way through for La Real, who have scored the second-least goals in the division this term.