The study highlights the crucial role of succinyl-CoA in tumor immunity by inducing the succinylation of PD-L1. We identified the succinyltransferase CPT1A as a potential therapeutic target. CPT1A could be a valuable biomarker for evaluating the efficacy of anti-PD-1 therapy and suggests a promising treatment strategy.
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Fig. 1: Mitochondrial enzymes and immunotherapy outcomes.
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This is a summary of: Liang, L. et al. Alterations in PD-L1 succinylation shape anti-tumor immune responses in melanoma. Nat. Genet. https://doi.org/10.1038/s41588-025-02077-6 (2025).
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Unraveling the role of succinyl-CoA in tumor immunity. Nat Genet (2025). https://doi.org/10.1038/s41588-025-02076-7
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Published:11 March 2025
DOI:https://doi.org/10.1038/s41588-025-02076-7
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