N-monofluoromethyl amides (N-CH2F) have been challenging to prepare. Now, a general method for the synthesis of *N-*CH2F amides is developed. The strategy can be applied for the N-CH2F modification of peptides and drug derivatives. Moreover, the N-CH2F amides are relatively stable in various media, which could be beneficial for drug development.
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*Fig. 1: General method for the synthesis of N-CH2F amides, peptides and carbamates.*
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This is a summary of: Tao, M. et al. Preparation, separation and storage of N-monofluoromethyl amides and carbamates. Nat. Chem. https://doi.org/10.1038/s41557-025-01767-2 (2025).
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General strategy for the synthesis of N-monofluoromethyl amides. Nat. Chem. (2025). https://doi.org/10.1038/s41557-025-01769-0
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Published:11 March 2025
DOI:https://doi.org/10.1038/s41557-025-01769-0
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