At least $65 million slated for 14 of 35 Alzheimer's disease research centers is in limbo, with funding expected to run out on April 30. (The Guardian)
In a surprise finding, the silent X chromosome in female mice awakened late in life and turned on the brain-protective Plp1 gene. In humans, older women showed more PLP1 expression in the parahippocampus than older men. (Science Advances)
Denali Therapeutics said additional analyses of investigational DNL343 did not demonstrate a treatment effect on neurofilament light in people with amyotrophic lateral sclerosis (ALS).
Phosphorylated tau 181 and 217 were elevated in serum and muscle of ALS patients. (Nature Communications)
The open-label DAFFODIL study of trofinetide (Daybue) in young girls with Rett syndrome showed symptoms improved with no new safety signals. (Med)
Worldwide cases of Parkinson's disease are expected to reach 25 million by 2050, a model suggested. (The BMJ)
Blood and urine biomarkers were associated with Parkinson's disease and may help identify patients before clinical diagnosis. (npj Parkinson's Disease)
Tris Pharma announced positive topline results from the ALLEVIATE-2 phase III clinical trial of investigational cebranopadol to treat moderate-to-severe acute pain after bunionectomy surgery.
Axonal spheroids found around amyloid deposits may be a therapeutic target in Alzheimer's disease. (Nature Aging)
Microglial mechanisms appeared to drive amyloid-beta clearance in immunized Alzheimer's patients. (Nature Medicine)
Self-perceived stress was correlated with a higher risk of cryptogenic ischemic stroke in young women but not in young men, data from the SECRETO study showed. (Neurology)
Judy George covers neurology and neuroscience news for MedPage Today, writing about brain aging, Alzheimer’s, dementia, MS, rare diseases, epilepsy, autism, headache, stroke, Parkinson’s, ALS, concussion, CTE, sleep, pain, and more. Follow