Frontotemporal dementias can be caused by mutations in MAPT, which encodes the protein tau; the mutant protein forms harmful aggregates in the brain. Cryo-electron microscopy of tau filaments from individuals with mutant V337M and R406W tau show the Alzheimer fold.
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Fig. 1: Cryo-EM cross sections of filaments.
References
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This is a summary of: Qi, C. et al. Tau filaments with the Alzheimer fold in human MAPT mutants V337M and R406W. Nat. Struct. Mol. Biol. https://doi.org/10.1038/s41594-025-01498-5 (2025).
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Mutant tau filaments from some inherited frontotemporal dementias show the Alzheimer fold. Nat Struct Mol Biol (2025). https://doi.org/10.1038/s41594-025-01499-4
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Published:12 March 2025
DOI:https://doi.org/10.1038/s41594-025-01499-4
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