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Biophysics in kinase drug discovery: FBS to PROTAC® ternary complex characterisation

Vanessa Porkolab, PhD, Biophysics Director – Eurofins Cerep

Dr. Porkolab manages the Biophysics Platform for drug discovery projects at Eurofins Cerep. Prior to joining as Biophysics Director in 2022, she was Team leader, Senior Scientist in Biophysics in another European CRO and Biotech working on fragments, small-molecules, antibodies and aptamer-based drug discovery programs. With her scientific team, she is involved in integrated projects spanning target validation, high-throughput screening campaigns and hit-to-lead to lead optimisation. She completed her PhD at the Institut de Biologie Structurale (IBS) in Grenoble, France where she worked on multidisciplinary drug design projects targeting carbohydrate-based proteins involved in the immune response. She then moved to Brandeis University near Boston, USA where her postdoctoral studies were focused on RNA display and biophysical characterisation of glycopeptides for anti-HIV Abs.

Maud Sigoillot, PhD, Biophysics Research Scientist – Eurofins Cerep

Dr Sigoillot is a Project Leader for Biophysics Projects. She works closely with clients to define the most effective biophysical strategy and is responsible for the integrity of the scientific data of the project.

DSigoillot obtained her PhD [at the University of Burgundy in 2011, specialising in the perception of sweet and umami tastes mediated by G-Protein Coupled Receptors (GPCRs). Subsequently, she deepened her knowledge of GPCR biochemistry during a first postdoctoral experience at Tsinghua University (China). Back in Europe, she focused on engineering nanobodies to treat cystic fibrosis at the University of Brussels (ULB, Belgium) and had the opportunity to join Chromacure biotech as a Research Scientist to develop complementary biophysical assays targeting orphan nuclear receptors in the context of drug discovery programs in oncology.

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The webinar will take place live on 6 December at 16:00 UK Time

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During the live webinar, you’ll be able to ask the speakers your questions, which will then be answered during the live Q&A session towards the end of the webinar.

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This webinar will last for up to one hour.

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Yes, you will receive a certificate if you attend the webinar live. The certificate will be sent with your on-demand video link.

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