Researchers in Gastroenterology evaluated strategies for preventing avoidable colorectal cancers after colonoscopy.
In related news, a third of adenomas could be missed with white-light colonoscopy, contributing to interval cancers, a meta-analysis suggested. (BMC Gastroenterology)
A phase I/II gene-editing trial restored a mutated gene to normal in patients with alpha-1 antitrypsin deficiency, a rare disorder that causes liver and lung damage, said Beam Therapeutics.
Benefits of simultaneous sleeve gastrectomy during liver transplant may include lower diabetes prevalence and lower incidence of allograft steatosis, a retrospective cohort study found. (Journal of Hepatology)
The British Society of Gastroenterology released guidelines on managing gastrointestinal symptoms and complications from cancer treatment. (Gut)
And a clinical guideline from the American College of Gastroenterology covered the diagnosis and management of premalignant stomach conditions. (American Journal of Gastroenterology)
Real-world data confirmed the effectiveness of upadacitinib (Rinvoq) in Crohn's disease, with clinical remission achieved in 56% of patients at 6 months, including 41% of those previously exposed to two or more advanced therapies. (Clinical Gastroenterology and Hepatology)
In the phase IIb ANTHEM-UC study of moderately to severely active ulcerative colitis, the novel IL-23 receptor blocker icotrokinra met its primary endpoint of clinical response, Johnson & Johnson announced.
And Agomab's novel ALK5 inhibitor (AGMB-129) met its primary endpoint in a phase II trial of fibrostenosing Crohn's disease, the company announced.
Tapering prednisolone reduced the risk of infection in patients with severe alcohol-associated hepatitis without impacting other key outcomes like mortality, the randomized STASH trial indicated. (American Journal of Gastroenterology)
Here's how artificial intelligence could influence clinical practice in inflammatory bowel disease (IBD) care. (Gastroenterology)
In a randomized trial, the antispasmodic mebeverine failed to improve outcomes in adolescent irritable bowel syndrome (IBS). (Gastroenterology)
IBS prevalence among Norwegians in IBD remission was roughly twice that of the general population, a cohort study found. (Inflammatory Bowel Diseases)
Clinical Gastroenterology and Hepatology reviewed how geriatric syndromes affect older IBD patients.
Worse scores on the index of severity for eosinophilic esophagitis (I-SEE) was associated with lower response to topical steroids. (Clinical Gastroenterology and Hepatology)
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Ian Ingram is Managing Editor at MedPage Today and helps cover oncology for the site.