Scientists who examined the impact of an H5N1 avian flu outbreak in an Ohio dairy herd that had about 3,900 cows found a milk production drop in clinically affected cows that lasted 60 days and extensive asymptomatic infections in other cows. The team, led by researchers at Cornell University, published their findings as a preprint study in Nature Portfolio.
The first illness in the herd was noted about 2 weeks after apparently healthy lactating cows from Texas were introduced into the herd. Decreased rumination and a decline in milk production appeared to decline about 5 days before clinical diagnosis.
Significant production consequences
The researchers observed clinical disease in about 20% of cows, with milk losses of about 900 kg per cow in the 60-day period that followed the outbreak. They estimated the economic loss at $950 per clinically affected cow. Combined with mortality and herd removal, the team estimated the total cost of the outbreak in the herd as $737,500 over the observation period.
Higher risks were seen in multiparous cows when compared with those that were lactating for the first time, an observation that has been seen before, which the group said may suggest a link between cumulative exposure to the milking process and the risk of clinical disease.
Seroprevalance findings were positive for nearly 90% of the 637 animals that were on the farm during the clinical phase of the outbreak, suggesting high transmission efficacy. Notably, antibodies were seen in 17 of 42 cows that were in the dry phase, hinting that nonlactating cows can also be the source of the virus.
“Although the precise mechanism of transmission of HPAI H5N1 virus in dairy cattle remains unknown, this is consistent with infections with other influenza A viruses which can quickly spread through susceptible mammalian populations including in humans, dogs and swine,” they wrote.
More confirmations in US dairy cows, mammals, and poultry
In outbreak developments, the US Department of Agriculture (USDA) Animal and Plant Health Inspection Service (APHIS) confirmed two more H5N1 in dairy cattle, both from Idaho, raising the national total to 985. Idaho has now reported three detections over the past few weeks.
The Idaho State Department of Agriculture said three facilities are currently quarantined, all from Gooding County.
Also, APHIS reported nine more detections in mammals, including domestic cats from New Jersey, Idaho, and Kansas. Officials also confirmed H5N1 in a harbor seal from Washington and mice from Missouri’s Newton County.
In poultry developments, APHIS confirmed more detections in backyard poultry from five states, including Iowa, Nebraska, New York, Colorado, and Indiana, along with detections in two more live poultry markets in New York, one in Queens and the other in Kings County.