Sarcopenia is one of the main contributors to the loss of independence in older adults. A study in primates demonstrates that SIRT5-mediated desuccinylation of TBK1 at Lys137 inhibits the activation of TBK1 and its downstream pro-inflammatory responses, thereby protecting skeletal muscle from ageing.
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Fig. 1: SIRT5-mediated TBK1 desuccinylation delays skeletal muscle ageing.
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Authors and Affiliations
Department of Biology, University of Rochester, Rochester, NY, USA
Vera Gorbunova & Andrei Seluanov
Department of Medicine, University of Rochester Medical Center, Rochester, NY, USA
Vera Gorbunova & Andrei Seluanov
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Vera Gorbunova
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2. Andrei Seluanov
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Correspondence to Vera Gorbunova or Andrei Seluanov.
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V.G. is a member of the scientific advisory boards of GenFlow Bio, Do Not Age, Elysium, Matrix Bio, Faunsome, BellSant and WndrHlth. A.S. declares no competing interests.
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Gorbunova, V., Seluanov, A. SIRT5 slows skeletal muscle ageing by alleviating inflammation. Nat Metab (2025). https://doi.org/10.1038/s42255-025-01228-7
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Published:14 March 2025
DOI:https://doi.org/10.1038/s42255-025-01228-7
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